Two Postdoctoral Postdoctoral Associate positions are available in the Laboratory of Developmental Neurobiology at the Yale University School of Medicine.
The first position is to investigate the molecular mechanisms of neuronal regeneration and recovery in a mouse model of perinatal hypoxia, focusing on a cellular and molecular analysis of neural stem and progenitor cells and their transcriptome. Our approaches also involve genetic fate mapping and the use of inducible gene knockouts to study the role of growth factor signaling in astroglia and neural stem cells during the regeneration/recovery period.
The second position is to investigate the cellular and molecular aspects of developmental disorders, such as Tourette syndrome and autism spectrum disorders using human specimens. At a basic level, we will generate induced pluripotent cells for these disorders and study their genome and transcriptome as they differentiate into neurons in vitro. At the system level, we use postmortem human tissue to perform a systematic analysis of excitatory and inhibitory neuron subtypes in the basal ganglia and cerebral cortical regions using stereological techniques.
The newly-renovated lab is at the Child Study Center, in the main Medical School campus. The candidate will be involved in multidisciplinary research at the interface of human and mouse development, and will have the opportunity to develop mouse models related to human brain disorders.
Requirements
The candidates must have a Ph. D. or M.D. and will have expertise in one or more of the following areas, depending on which one of the two positions is selected: molecular genetics, developmental neurobiology, human and mouse stem cell techniques, or primate/human brain anatomy. Candidates with expertise in transgenic and BAC technologies and whole genome/transcriptome analyses are encouraged to apply.
The candidate must have an excellent command of written and spoken English language, and will be expected to work relatively independently and write papers and grant proposals. We seek individuals that will eventually mature to be independent principal investigators within the program.
Application
Interested candidates should send a CV, a statement of research interests and the names of two references to flora.vaccarino@yale.edu
0 comments:
Post a Comment