Exploring Conserved Non-Coding sequences using comparative genomics We are looking for a highly motivated and innovative PhD candidate to explore the evolution and patterns of selection acting on Conserved Non-Coding sequences (CNCs) in vertebrates using computational comparative genomics.
It is estimated that about 4-7% of the human genome is under functional selection, yet only 2% encodes proteins. This implies that there is a repertoire of functionally important elements at least as large as the repertoire of protein-coding genes, whose functions remain largely unknown. The project will develop our lead findings and will benefit from established collaborations.
The ideal candidate should have a strong background in bioinformatics, including programming skills, and a good understanding of molecular biology and evolution. A Diploma or MSc degree in Biology or Bioinformatics, practical experience in the Unix environment, and fluency in English are required.
The project will be supervised by Prof. E. Zdobnov, heading the Computational Evolutionary Genomics group at the Department of Genetic Medicine and Development of the University of Geneva Medical School. We are also part of the renowned Swiss Institute of Bioinformatics, and offer a stimulating research environment with excellentfacilities.
The international city of Geneva, described as ‘the smallest of the large capitals’, offers a vibrant city life within easy reach of the picturesque lake and stunning Alps.
Closing date for applications: 31 May 2009.
To apply: send your CV, motivation letter, and the names and contact details of at least two referees by e-mail to Evgeny.Zdobnov@isb-sib.ch
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